SPM Active (120 ct)

Specialized Pro-Resolving Mediators (SPMs) act as chemical messengers in the body's immune response. They are produced at affected part of the body and help to resolve inflammation.

How are SPMs different from omega-3 fatty acids?

Although our body can use omega-3 fatty acids like EPA and DHA to generate SPMs, there are many enzymatic steps involved in this process. The impact of aging, poor diet and general health status can inhibit the body's production of SPMs from these fatty acids. Supplementing with SPMs directly provides a more targeted and direct support for the body's affected tissues to return to health.

Research supports the idea that pro-resolving mediators (aka resolvins) may help reduce inflammation, including neuroinflammation:

Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses.

Resolvin D1 promotes the interleukin-4-induced alternative activation in BV-2 microglial cells.

Metagenics offers a natural essential fatty acid supplement called SPM Active that seeks to support cell and tissue health, and immune response.

• An omega fatty acid formula
• Specialized pro-resolving mediators
• Contains 250mg of a fractionated lipid concentrate
• Made with fish oil (anchovy and sardine)
• Purity guaranteed
• Gluten free
• 60 softgels

This formula's SPM content is standardized to 18-HEPE and 17-HDHA. It should be stored in a dry, cool place. Recommended use is to take two softgels once daily or as directed by a healthcare provider.